Abstract
Experimental allergic sialoadenitis was induced in immunized rats by intraductal challenge with the sensitizing antigen. Intraductal instillation of preformed immune complexes in non-immunized animals caused a similar inflammatory reaction. Treatment of immunized and intraductally challenged rats with antihistamine prevented the development of sialoadenitis. Administration of antiserotonin did not inhibit the inflammatory process. The findings support the contention that deposition of immune complexes in the salivary gland is responsible for the ensuing sialoadenitis.
Original language | English |
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Pages (from-to) | 283-288 |
Number of pages | 6 |
Journal | Virchows Archiv |
Volume | 359 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1973 |