Experimental allergic sialoadenitis - VI. Prevention by antihistamine and induction by intraductal instillation of preformed immune complexes

T. Dishon*, J. Sela, M. Ulmansky, E. Rosenmann, J. H. Boss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Experimental allergic sialoadenitis was induced in immunized rats by intraductal challenge with the sensitizing antigen. Intraductal instillation of preformed immune complexes in non-immunized animals caused a similar inflammatory reaction. Treatment of immunized and intraductally challenged rats with antihistamine prevented the development of sialoadenitis. Administration of antiserotonin did not inhibit the inflammatory process. The findings support the contention that deposition of immune complexes in the salivary gland is responsible for the ensuing sialoadenitis.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalVirchows Archiv
Volume359
Issue number4
DOIs
StatePublished - Dec 1973

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