Experimental Measurement of the Strength of a Cα-H⋯O Bond in a Lipid Bilayer

Eyal Arbely, Isaiah T. Arkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Due to the apolar nature of the lipid bilayer, the weak Cα-H···O H-bond is thought to contribute significantly toward the stability of transmembrane helical bundles such as glycophorin A (GPA). Here for the first time we measured the strength of such a bond, using vibrational frequency shifts of a dimeric and nondimeric variants of GPA containing a Gly CD2 label. Although the resulting estimated bond strength of 0.88 kcal/mol is relatively weak, several such bonds could contribute significantly toward bundle stabilization.

Original languageAmerican English
Pages (from-to)5362-5363
Number of pages2
JournalJournal of the American Chemical Society
Issue number17
StatePublished - 5 May 2004


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