Expert opinion on three phage therapy related topics: Bacterial phage resistance, phage training and prophages in bacterial production strains

Christine Rohde, Grégory Resch, Jean Paul Pirnay, Bob G. Blasdel, Laurent Debarbieux, Daniel Gelman, Andrzej Górski, Ronen Hazan, Isabelle Huys, Elene Kakabadze, Małgorzata Łobocka, Alice Maestri, Gabriel Magno De Freitas Almeida, Khatuna Makalatia, Danish J. Malik, Ivana Mašlaňová, Maia Merabishvili, Roman Pantucek, Thomas Rose, Dana ŠtverákováHilde Van Raemdonck, Gilbert Verbeken, Nina Chanishvili*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.

Original languageAmerican English
Article number178
JournalViruses
Volume10
Issue number4
DOIs
StatePublished - Apr 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Adaptation
  • Bacteriophage
  • Phage therapy
  • Production
  • Prophage
  • Regulation
  • Resistance

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