Exploration of Macroporous Polymeric Sponges As Drug Carriers

Gaigai Duan, Amir Reza Bagheri, Shaohua Jiang, Jacob Golenser, Seema Agarwal, Andreas Greiner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.

Original languageEnglish
Pages (from-to)3215-3221
Number of pages7
JournalBiomacromolecules
Volume18
Issue number10
DOIs
StatePublished - 9 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

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