TY - JOUR
T1 - Exploration of Macroporous Polymeric Sponges As Drug Carriers
AU - Duan, Gaigai
AU - Bagheri, Amir Reza
AU - Jiang, Shaohua
AU - Golenser, Jacob
AU - Agarwal, Seema
AU - Greiner, Andreas
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/10/9
Y1 - 2017/10/9
N2 - Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.
AB - Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.
UR - http://www.scopus.com/inward/record.url?scp=85031283678&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.7b00852
DO - 10.1021/acs.biomac.7b00852
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C2 - 28820944
AN - SCOPUS:85031283678
SN - 1525-7797
VL - 18
SP - 3215
EP - 3221
JO - Biomacromolecules
JF - Biomacromolecules
IS - 10
ER -