TY - JOUR
T1 - Exploring the Iris haynei essential oil
T2 - analysis of phytochemical composition, evaluation of cytotoxicity, antimicrobial properties, and AMPA receptor modulation
AU - Jaradat, Nidal
AU - Qneibi, Mohammad
AU - Hawash, Mohammed
AU - Qadi, Mohammad
AU - Al-Maharik, Nawaf
AU - Bdir, Sosana
AU - Bdair, Mohammad
AU - Bshir, Jwana
AU - Saleh, Nadeen
AU - Ighbarieh, Mais
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Background: The complex composition of essential oils (EOs) derived from plants offers potential therapeutic approaches for treating various medical conditions, including neurological disorders and infectious diseases. This research aimed to comprehensively analyze the phytochemical composition of Iris haynei EO and evaluate its pharmacological properties, specifically its cytotoxicity, antimicrobial activity, and modulation of AMPA receptors. Results: The analysis of I. haynei EO, conducted using gas chromatography and mass spectroscopy, identified diethyl phthalate, α-terpineol, and benzyl acetate as the main components. Cytotoxicity experiments on several cancer cell lines revealed a dose-dependent impact. Electrophysiological recordings on HEK293T cells expressing AMPARs showed varying levels of inhibition across different subunits, with receptors encoding GluA2 exhibiting the most significant effects. The EO also demonstrated significant antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as fungi. Conclusions: The findings of this study underscore the potential therapeutic benefits of I. haynei EO, particularly in treating neurological conditions associated with AMPA receptor dysfunction and exhibiting antimicrobial activity against infectious agents. The promising results warrant further investigation into the pharmacological effects of the EO, suggesting a novel approach for addressing cerebral ischemia and related neurological diseases. Graphical Abstract: (Figure presented.)
AB - Background: The complex composition of essential oils (EOs) derived from plants offers potential therapeutic approaches for treating various medical conditions, including neurological disorders and infectious diseases. This research aimed to comprehensively analyze the phytochemical composition of Iris haynei EO and evaluate its pharmacological properties, specifically its cytotoxicity, antimicrobial activity, and modulation of AMPA receptors. Results: The analysis of I. haynei EO, conducted using gas chromatography and mass spectroscopy, identified diethyl phthalate, α-terpineol, and benzyl acetate as the main components. Cytotoxicity experiments on several cancer cell lines revealed a dose-dependent impact. Electrophysiological recordings on HEK293T cells expressing AMPARs showed varying levels of inhibition across different subunits, with receptors encoding GluA2 exhibiting the most significant effects. The EO also demonstrated significant antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as fungi. Conclusions: The findings of this study underscore the potential therapeutic benefits of I. haynei EO, particularly in treating neurological conditions associated with AMPA receptor dysfunction and exhibiting antimicrobial activity against infectious agents. The promising results warrant further investigation into the pharmacological effects of the EO, suggesting a novel approach for addressing cerebral ischemia and related neurological diseases. Graphical Abstract: (Figure presented.)
KW - AMPA receptors
KW - Antimicrobial
KW - Cytotoxicity
KW - GluA2
KW - Iris haynei
KW - Phytochemistry
UR - http://www.scopus.com/inward/record.url?scp=85201708692&partnerID=8YFLogxK
U2 - 10.1186/s40538-024-00636-3
DO - 10.1186/s40538-024-00636-3
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AN - SCOPUS:85201708692
SN - 2196-5641
VL - 11
JO - Chemical and Biological Technologies in Agriculture
JF - Chemical and Biological Technologies in Agriculture
IS - 1
M1 - 117
ER -