Abstract
The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2-12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 ± 3.4 pmol/min/embryo and 2.3 ± 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalasin B. These results suggest that, although GLUT-1 is expressed in human oocytes and throughout preimplantation development, its function in mediating the rise in glucose uptake is triggered following fertilization.
Original language | English |
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Pages (from-to) | 2508-2510 |
Number of pages | 3 |
Journal | Human Reproduction |
Volume | 12 |
Issue number | 11 |
DOIs | |
State | Published - 1997 |
Keywords
- Glucose transporter
- Glucose uptake
- GLUT-1
- Oocytes
- Preimplantation embryos