Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos

Mary Dan-Goor, Shlomo Sasson, Anna Davarashvili, Miriam Almagor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2-12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 ± 3.4 pmol/min/embryo and 2.3 ± 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalasin B. These results suggest that, although GLUT-1 is expressed in human oocytes and throughout preimplantation development, its function in mediating the rise in glucose uptake is triggered following fertilization.

Original languageEnglish
Pages (from-to)2508-2510
Number of pages3
JournalHuman Reproduction
Volume12
Issue number11
DOIs
StatePublished - 1997

Keywords

  • Glucose transporter
  • Glucose uptake
  • GLUT-1
  • Oocytes
  • Preimplantation embryos

Fingerprint

Dive into the research topics of 'Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos'. Together they form a unique fingerprint.

Cite this