Expression of hindbrain boundary markers is regulated by FGF3

Karen Weisinger, Ayelet Kohl, Galya Kayam, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Compartment boundaries act as organizing centers that segregate adjacent areas into domains of gene expression and regulation, and control their distinct fates via the secretion of signalling factors. During hindbrain development, a specialized cell-population forms boundaries between rhombomeres. These boundary cells demonstrate unique morphological properties and expressmultiple genes that differs them fromintra-rhombomeric cells. Yet, little is known regarding the mechanisms that controls the expression or function of these boundary markers. Multiple components of the FGF signaling system, including ligands, receptors, downstream effectors as well as proteoglycans are shown to localize to boundary cells in the chick hindbrain. These patterns raise the possibility that FGF signaling plays a role in regulating boundary properties. We provide evidence to the role of FGF signaling, particularly the boundary-derived FGF3, in regulating the expression of multiple markers at hindbrain boundaries. These findings enable further characterization of the unique boundary-cell population, and expose a new function for FGFs as regulators of boundary-gene expression in the chick hindbrain.

Original languageAmerican English
Pages (from-to)67-74
Number of pages8
JournalBiology Open
Issue number2
StatePublished - 15 Feb 2012

Bibliographical note

Publisher Copyright:
© 2011. Published by The Company of Biologists Ltd.


  • Boundary cells
  • Chick embryo
  • FGF
  • Hindbrain
  • Rhombomere
  • Signaling pathway


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