Extended repertoire of genes encoding variable surface lipoproteins in Mycoplasma bovis strains

Sarit Nussbaum, Inessa Lysnyansky, Konrad Sachse, Sharon Levisohn, David Yogev*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A genomic cluster of vsp genes was previously shown to mediate high-frequency phenotypic switching of surface lipoprotein antigens in the bovine pathogen Mycoplasma bovis. This study revealed that field strains of M. bovis possess modified versions of the vsp gene complex in which extensive sequence variations occur primarily in the reiterated coding sequences of the vsp structural genes. These findings demonstrate that there is a vastly expanded potential for antigenic variation within populations of this organism.

Original languageAmerican English
Pages (from-to)2220-2225
Number of pages6
JournalInfection and Immunity
Volume70
Issue number4
DOIs
StatePublished - 2002

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