Extending SEE for large-scale phenotyping of mouse open-field behavior

Neri Kafkafi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


SEE (Software for the Exploration of Exploration) is a visualization and analysis tool designed for the study of open-field behavior in rodents. In this paper, I present new extensions of SEE that were designed to facilitate its use for mouse behavioral phenotyping and, especially, for the problems of discrimination of genotypes and the replication of results across laboratories and experimental conditions. These extensions were specifically designed to promote a new approach in behavioral phenotyping, reminiscent of the approach that has been successfully employed in bioinformatics during recent years. The path coordinates of all animals from many experiments are stored in a database. SEE can be used to query, visualize, and analyze any desirable subsection of this database and to design new measures (endpoints) with increasingly better discriminative power and replicability. The use of the new extensions is demonstrated here in the analysis of results from several experiments and laboratories, with an emphasis on this approach.

Original languageAmerican English
Pages (from-to)294-301
Number of pages8
JournalBehavior Research Methods, Instruments, and Computers
Issue number2
StatePublished - May 2003
Externally publishedYes


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