F-spondin and mindin: Two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons

Yael Feinstein, Víctor Borrell, Cristina Garcia, Tal Burstyn-Cohen, Vered Tzarfaty, Ayala Frumkin, Akinao Nose, Hitoshi Okamoto, Shin Ichi Higashijima, Eduardo Soriano, Avihu Klar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Extracellular matrix (ECM) proteins play an important role in early cortical development, specifically in the formation of neural connections and in controlling the cyto-architecture of the central nervous system. F-spondin and Mindin are a family of matrix-attached adhesion molecules that share structural similarities and overlapping domains of expression. Genes for both proteins contain a thrombospondin type I repeat(s) at the C terminus and an FS1-FS2 (spondin) domain. Both the vertebrate F-spondin and the zebrafish mindins are expressed on the embryonic floor plate. In the current study we have cloned the rat homologue of mindin and studied its expression and activity together with F-spondin in the developing rodent brain. The two genes are abundantly expressed in the developing hippocampus. In vitro studies indicate that both F-spondin and Mindin promote adhesion and outgrowth of hippocampal embryonic neurons. We have also demonstrated that the two proteins bind to a putative receptor(s) expressed on both hippocampal and sensory neurons.

Original languageAmerican English
Pages (from-to)3637-3648
Number of pages12
JournalJournal of Embryology and Experimental Morphology
Volume126
Issue number16
StatePublished - Aug 1999

Keywords

  • Adhesion
  • F-spondin
  • Hippocampus
  • Mindin
  • Neurite outgrowth
  • Rat

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