Facilitating a culture of responsible and effective sharing of cancer genome data

Lillian L. Siu; Mark Lawler; David Haussler; Bartha Maria Knoppers; Jeremy Lewin; Daniel J. Vis; Rachel G. Liao; Fabrice Andre; Ian Banks; J. Carl Barrett; Carlos Caldas; Anamaria Aranha Camargo; Rebecca C. Fitzgerald; Mao Mao; John E. Mattison; William Pao; William R. Sellers; Patrick Sullivan; Bin Tean Teh; Robyn L. Ward; Jean Claude ZenKlusen; Charles L. Sawyers; Emile E. Voest

doi:10.1038/nm.4089

Facilitating a culture of responsible and effective sharing of cancer genome data

Lillian L. Siu
, Mark Lawler^*
, David Haussler
, Bartha Maria Knoppers
, Jeremy Lewin
, Daniel J. Vis
, Rachel G. Liao
, Fabrice Andre
, Ian Banks
, J. Carl Barrett
, Carlos Caldas
, Anamaria Aranha Camargo
, Rebecca C. Fitzgerald
, Mao Mao
, John E. Mattison
, William Pao
, William R. Sellers
, Patrick Sullivan
, Bin Tean Teh
, Robyn L. Ward

Jean Claude ZenKlusen, Charles L. Sawyers, Emile E. Voest

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.

Original language	English
Title of host publication	Getting to Good
Subtitle of host publication	Research Integrity in the Biomedical Sciences
Publisher	Springer International Publishing
Pages	539-548
Number of pages	10
ISBN (Electronic)	9783319513584
ISBN (Print)	9783319513577
DOIs	https://doi.org/10.1038/nm.4089
State	Published - 23 Jul 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Nature Medicine.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nm.4089

Cite this

Siu, L. L., Lawler, M., Haussler, D., Knoppers, B. M., Lewin, J., Vis, D. J., Liao, R. G., Andre, F., Banks, I., Barrett, J. C., Caldas, C., Camargo, A. A., Fitzgerald, R. C., Mao, M., Mattison, J. E., Pao, W., Sellers, W. R., Sullivan, P., Teh, B. T., ... Voest, E. E. (2018). Facilitating a culture of responsible and effective sharing of cancer genome data. In Getting to Good: Research Integrity in the Biomedical Sciences (pp. 539-548). Springer International Publishing. https://doi.org/10.1038/nm.4089

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abstract = "Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.",

author = "Siu, \{Lillian L.\} and Mark Lawler and David Haussler and Knoppers, \{Bartha Maria\} and Jeremy Lewin and Vis, \{Daniel J.\} and Liao, \{Rachel G.\} and Fabrice Andre and Ian Banks and Barrett, \{J. Carl\} and Carlos Caldas and Camargo, \{Anamaria Aranha\} and Fitzgerald, \{Rebecca C.\} and Mao Mao and Mattison, \{John E.\} and William Pao and Sellers, \{William R.\} and Patrick Sullivan and Teh, \{Bin Tean\} and Ward, \{Robyn L.\} and ZenKlusen, \{Jean Claude\} and Sawyers, \{Charles L.\} and Voest, \{Emile E.\}",

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doi = "10.1038/nm.4089",

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Siu, LL, Lawler, M, Haussler, D, Knoppers, BM, Lewin, J, Vis, DJ, Liao, RG, Andre, F, Banks, I, Barrett, JC, Caldas, C, Camargo, AA, Fitzgerald, RC, Mao, M, Mattison, JE, Pao, W, Sellers, WR, Sullivan, P, Teh, BT, Ward, RL, ZenKlusen, JC, Sawyers, CL & Voest, EE 2018, Facilitating a culture of responsible and effective sharing of cancer genome data. in Getting to Good: Research Integrity in the Biomedical Sciences. Springer International Publishing, pp. 539-548. https://doi.org/10.1038/nm.4089

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AU - Mattison, John E.

AU - Pao, William

AU - Sellers, William R.

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AU - Teh, Bin Tean

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AB - Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.

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Facilitating a culture of responsible and effective sharing of cancer genome data

Abstract

Bibliographical note

UN SDGs

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