Factors influencing the adrenergic neurone blocking action of propranolol

SARAH ELIASH*, MARTA WEINSTOCK

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The reversal by propranolol of its own adrenergic neurone blocking effect in the cat can be prevented by cutting the splanchnic nerves or by ligating the adrenal veins. In the absence of secretion from the adrenal medulla the nerve blocking action of propranolol is more complete, but can still be reversed by repeated injections or a constant infusion of adrenaline. Prior treatment with adrenaline or noradrenaline also prevents the development of the blocking action of propranolol in the cat and in the isolated guinea‐pig vas deferens. It is suggested that in the cat, propranolol stimulates the release of catecholamines from the adrenal medulla which antagonize its nerve blocking effect. 1972 British Pharmacological Society

Original languageEnglish
Pages (from-to)630-634
Number of pages5
JournalBritish Journal of Pharmacology
Volume45
Issue number4
DOIs
StatePublished - Aug 1972
Externally publishedYes

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