TY - JOUR
T1 - Factors regulating basement membrane invasion by tumor cells.
AU - Thompson, E. W.
AU - Reich, R.
AU - Martin, G. R.
AU - Albini, A.
PY - 1988
Y1 - 1988
N2 - Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
AB - Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=0024154598&partnerID=8YFLogxK
U2 - 10.1007/978-1-4613-1733-3_11
DO - 10.1007/978-1-4613-1733-3_11
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C2 - 2908653
AN - SCOPUS:0024154598
SN - 0927-3042
VL - 40
SP - 239
EP - 249
JO - Cancer Treatment and Research
JF - Cancer Treatment and Research
ER -