Failure of insulin-like growth factor 1 to improve radiocontrast nephropathy

S. Fuchs, R. Yaffe, R. Beeri, S. Rosen, S. N. Heyman, M. Brezis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Exogenous insulin-like growth factor 1 (IGF-1) has been reported to improve experimental ischemic acute renal failure. We investigated a possible beneficial role of IGF-1 in a model of radiocontrast nephropathy induced by indomethacin, nitro-L-arginine ester and iothalamate. Multiple injections of recombinant human IGF-1 (or its vehicle) at 150 μg/100 g body weight/day were given for 24 h starting 1 h after radiocontrast, or initiated 1 day after the insults and continued for 48 h. IGF-1 prevented neither the fall in creatinine clearance nor medullary thick ascending limb necrosis observed at 24 h. Similarly IGF-1, given for 2 days after renal failure had been established, did not accelerate functional recovery at 72 h, did not ameliorate catabolism and did not alter the morphological evolution of intrarenal damage. In conclusion, IGF-1 had no beneficial effects in this model of radiocontrast nephropathy.

Original languageAmerican English
Pages (from-to)88-94
Number of pages7
JournalExperimental Nephrology
Volume5
Issue number1
StatePublished - Jan 1997
Externally publishedYes

Keywords

  • TUNEL
  • apoptosis
  • radiocontrast nephropathy
  • thick ascending limb

Fingerprint

Dive into the research topics of 'Failure of insulin-like growth factor 1 to improve radiocontrast nephropathy'. Together they form a unique fingerprint.

Cite this