Familial oral lichen planus: A new risk group for oral cancer?

Rakefet Czerninski*, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations


    Objective: The familial type of oral lichen planus (OLP) is rare, with a paucity of data regarding its clinical significance. Our objective was to characterize patients with familial OLP. Methods: Families with at least two members diagnosed with OLP were included. Clinical and demographic data and medical history were recorded. Results: Twenty families, 19 Jewish and 1 Arab, were identified. Of the Jewish families, 57.8% were non-Ashkenazi, originating mainly from central Asia. Of those with OLP there were 14 males and 23 females with an average age of 49.1. Dyslipidemia, cardiovascular, and thyroid disorders (27.7%, 22.2%, and 16.6%, respectively) were the most common comorbidities. Five patients from five distinct families had oral cancer, two with second primary. Conclusions: To the best of our knowledge, this is the largest study describing familial OLP. The predominant and common ethnicity of the families with multiple members diagnosed with OLP may imply an ethnic tendency. The higher tendency of hypothyroidism and the high percentage of OSCC among familial OLP patients might be connected to familial OLP and the latter suggests that this population is predisposed to malignant transformation. Thus, this group should be considered as a high-risk group.

    Original languageAmerican English
    JournalOral Diseases
    Early online date20 Nov 2023
    StateE-pub ahead of print - 20 Nov 2023

    Bibliographical note

    Publisher Copyright:
    © 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.


    • lichen planus
    • oral carcinoma
    • oral diseases
    • thyroid


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