Fatty acids composition of human milk fed to small for gestational age infants

Ronit Lubetzky, Nurit Argov-Argaman, Francis B. Mimouni, Keren Armoni Domany, Yaffa Shiff, Zipi Berkovitz, Ram Reifen, Dror Mandel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: To test the null hypothesis that mothers of asymmetric small for gestational age (SGA) infants produce milk with fatty acids composition similar to that of lactating mothers of appropriate-for-gestational-age (AGA) infants. Methods: We obtained human milk (HM) from 2 groups of lactating volunteers that gave birth to asymmetric SGA (study group) or AGA infants (control group). Each mother was asked to contribute by manual expression at least one of 3 samples: first 72 hours after labor (colostrum), day 2-7 postpartum (transitional milk) and 14 days post partum (mature milk). After lipid extraction using Folch's cold-extraction procedure fatty acids were analyzed using gas chromatography. Results: A total of 108 samples were obtained in 60 women. In univariate analysis, there were no significant differences in any of the fatty acids concentrations examined between groups. This remained true when timing of the sample (colostrum, transitional or mature milk) or gestational age were introduced as confounders in analysis of variance (general linear model). Conclusion: Fatty acid composition of human milk is not affected by whether or not the infant was fetal growth restricted. We suggest that mothers of SGA infants may be reassured about the fat quality of their milk.

Original languageAmerican English
Pages (from-to)3041-3044
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number18
StatePublished - 16 Sep 2016

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© 2015 Taylor & Francis.


  • Fat
  • fatty acids
  • human milk
  • small for gestation


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