Fatty acyl-coenzyme A elongation in brain of normal and quaking mice

Israel Goldberg*, Ishaiahu Shechter, Konrad Bloch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C20-CoA elongating system exists in mouse brain in addition to the previously recognized C16-CoA and C 18-CoA elongating enzymes. The C20-CoA elongation system is severely reduced in the mutant quaking mouse.

Original languageEnglish
Pages (from-to)497-499
Number of pages3
JournalScience
Volume182
Issue number4111
DOIs
StatePublished - 1973
Externally publishedYes

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