Fatty acyl-coenzyme A elongation in brain of normal and quaking mice

Israel Goldberg; Ishaiahu Shechter; Konrad Bloch

doi:10.1126/science.182.4111.497

Fatty acyl-coenzyme A elongation in brain of normal and quaking mice

Israel Goldberg^*
, Ishaiahu Shechter
, Konrad Bloch

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C₂₀-CoA elongating system exists in mouse brain in addition to the previously recognized C₁₆-CoA and C ₁₈-CoA elongating enzymes. The C₂₀-CoA elongation system is severely reduced in the mutant quaking mouse.

Original language	English
Pages (from-to)	497-499
Number of pages	3
Journal	Science
Volume	182
Issue number	4111
DOIs	https://doi.org/10.1126/science.182.4111.497
State	Published - 1973
Externally published	Yes

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title = "Fatty acyl-coenzyme A elongation in brain of normal and quaking mice",

abstract = "Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C20-CoA elongating system exists in mouse brain in addition to the previously recognized C16-CoA and C 18-CoA elongating enzymes. The C20-CoA elongation system is severely reduced in the mutant quaking mouse.",

author = "Israel Goldberg and Ishaiahu Shechter and Konrad Bloch",

year = "1973",

doi = "10.1126/science.182.4111.497",

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AU - Goldberg, Israel

AU - Shechter, Ishaiahu

AU - Bloch, Konrad

PY - 1973

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N2 - Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C20-CoA elongating system exists in mouse brain in addition to the previously recognized C16-CoA and C 18-CoA elongating enzymes. The C20-CoA elongation system is severely reduced in the mutant quaking mouse.

AB - Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C20-CoA elongating system exists in mouse brain in addition to the previously recognized C16-CoA and C 18-CoA elongating enzymes. The C20-CoA elongation system is severely reduced in the mutant quaking mouse.

UR - https://www.scopus.com/pages/publications/0015908994

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DO - 10.1126/science.182.4111.497

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Fatty acyl-coenzyme A elongation in brain of normal and quaking mice

Abstract

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