Features of neurovascular orofacial pain compared to painful posttraumatic trigeminal neuropathy

Yaron Haviv*, Avraham Zini, Naama Keshet, Galit Almoznino, Rafael Benoliel, Yair Sharav

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Aims: To test and re-examine the diagnostic criteria for neurovascular orofacial pain (NVOP) compared to posttraumatic trigeminal neuropathy (PTTN). Methods: Pain and patient characteristics were compared in patients with NVOP, PTTN, and NVOP initiated by trauma (PT-NVOP). NVOP criteria were based on prior studies, and PTTN was defined according to the International Classification of Headache Disorders, version 3 beta. Results: Of the 170 patients in the cohort, 90 had PTTN, 51 had NVOP, and 29 had PT-NVOP. None of the tested parameters in the NVOP and PT-NVOP patients were significantly different, and therefore these patients were combined into one group (T-NVOP). T-NVOP differed significantly from PTTN (P <.001) in periodic pain patterns, presence of autonomic anP d systemic signs, throbbing pain quality, and frequency of bilaterality. Pain quality in PTTN was more burning/stabbing than in NVOP (P =.003). Pain severity, waking from sleep, muscle sensitivity to palpation, and demographics were comparable. Conclusion: NVOP differs from PTTN in parameters essential to diagnosis: periodicity of pain, presence of autonomic and systemic accompanying signs, throbbing pain quality, and bilateral presentation. NVOP is amenable to abortive and prophylactic antimigraine therapies, distinguishing NVOP from PTTN in clinical features, treatment, and prognosis.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalJournal of Oral and Facial Pain and Headache
Issue number2
StatePublished - 2020
Externally publishedYes

Bibliographical note

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© 2020 by Quintessence Publishing Co Inc.


  • Migraine
  • Neurovascular orofacial pain
  • Persistent idiopathic facial pain
  • Post traumatic trigeminal neuropathy


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