Ferritin expression modulates cell cycle dynamics and cell responsiveness to H-ras-induced growth via expansion of the labile iron pool

Or Kakhlon, Yosef Gruenbaum, Z. Ioav Cabantchik*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations

    Abstract

    Repression or overexpression of ferritin accelerated or retarded cell cycling respectively, via changes in the cellular labile iron pool (LIP). A rise in LIP is caused by ferritin repression enhanced growth, induced by H-ras, and reverted growth arrest is induced by dominant negative H-ras. The studies indicate that repression of ferritin expression provides a mechanism by which certain oncogenes lead to cell growth stimulation.

    Original languageAmerican English
    Pages (from-to)431-436
    Number of pages6
    JournalBiochemical Journal
    Volume363
    Issue number3
    DOIs
    StatePublished - 1 May 2002

    Keywords

    • Antisense
    • Metals
    • Oncogenes

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