Fetal Alcohol Exposure Attenuates Lipopolysaccharide‐Induced Fever in Rats

Raz Yirmiya; Michelle L. Pilati; Francesco Chiappelli; Anna N. Taylor

doi:10.1111/j.1530-0277.1993.tb00862.x

Fetal Alcohol Exposure Attenuates Lipopolysaccharide‐Induced Fever in Rats

Raz Yirmiya^*, Michelle L. Pilati, Francesco Chiappelli, Anna N. Taylor

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Exposure to alcohol in utero can lead to long‐lasting impairments of immune functions and to decreased resistance to infectious agents. We studied the effects of fetal alcohol exposure (FAE) in rats on the core body temperature response to an exogenous challenge of the immune system with lipopolysaccharide (LPS). We report that FAE rats show markedly decreased LPS‐induced fever [i.e., they require a higher dose than control rats to show any LPS‐induced hyperthermia (50 μg/kg vs. 10 μg/kg)], and even with the higher LPS dose they manifest a weaker hyperthermia, which declines faster than in control animals. These results suggest that FAE produces an impairment in the release of endogenous pyrogens and/or in the neural substrate for body temperature regulation. This impairment may account for at least some of the decreased resistance to infections observed in FAE animals and humans.

Original language	English
Pages (from-to)	906-910
Number of pages	5
Journal	Alcoholism: Clinical and Experimental Research
Volume	17
Issue number	4
DOIs	https://doi.org/10.1111/j.1530-0277.1993.tb00862.x
State	Published - Aug 1993

Keywords

Endogenous Pyrogens
Fetal‐Alcohol Exposure
Fever
Immunosuppression
Lipopolysaccharide

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10.1111/j.1530-0277.1993.tb00862.x

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title = "Fetal Alcohol Exposure Attenuates Lipopolysaccharide‐Induced Fever in Rats",

abstract = "Exposure to alcohol in utero can lead to long‐lasting impairments of immune functions and to decreased resistance to infectious agents. We studied the effects of fetal alcohol exposure (FAE) in rats on the core body temperature response to an exogenous challenge of the immune system with lipopolysaccharide (LPS). We report that FAE rats show markedly decreased LPS‐induced fever [i.e., they require a higher dose than control rats to show any LPS‐induced hyperthermia (50 μg/kg vs. 10 μg/kg)], and even with the higher LPS dose they manifest a weaker hyperthermia, which declines faster than in control animals. These results suggest that FAE produces an impairment in the release of endogenous pyrogens and/or in the neural substrate for body temperature regulation. This impairment may account for at least some of the decreased resistance to infections observed in FAE animals and humans.",

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Fetal Alcohol Exposure Attenuates Lipopolysaccharide‐Induced Fever in Rats

Abstract

Keywords

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