Fetal cardiac ventricular volume, cardiac output, and ejection fraction determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis

Neil Hamill, Lami Yeo, Roberto Romero*, Sonia S. Hassan, Stephen A. Myers, Pooja Mittal, Juan Pedro Kusanovic, Mamtha Balasubramaniam, Tinnakorn Chaiworapongsa, Edi Vaisbuch, Jimmy Espinoza, Francesca Gotsch, Luis F. Goncalves, Wesley Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Objective: The objective of this study was to quantify fetal cardiovascular parameters using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL). Study Design: A cross-sectional study was performed in normal pregnancies (19-42 weeks) to evaluate ventricular volume, stroke volume (SV), cardiac output (CO), and ejection fraction (EF). The CO was also expressed as a function of estimated fetal weight and biometric parameters. Results: The following results were found: (1) 184 STIC datasets; (2) with advancing gestation, ventricular volume, SV, CO, and adjusted CO increased, whereas EF decreased; (3) right ventricular (RV) volume was larger than the left ventricular (LV) volume in systole (0.50 vs 0.27 mL; P < .001) and diastole (1.20 vs 1.03 mL; P < .001); (4) there were no differences between the LV and RV in SV, CO, or adjusted CO; and (5) LV EF was greater than the RV EF (72.2 vs 62.4%; P < .001). Conclusion: Normal fetal cardiovascular physiology is characterized by a larger RV volume and a greater LV EF, resulting in similar LV and RV SV and CO.

Original languageEnglish
Pages (from-to)76.e1-76.e10
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number1
DOIs
StatePublished - Jul 2011
Externally publishedYes

Keywords

  • 3-dimensional
  • 4-dimensional
  • contour finder
  • fetal echocardiography
  • fetus
  • prenatal diagnosis
  • sonography
  • spatiotemporal image correlation
  • STIC
  • stroke volume
  • ultrasound
  • virtual organ computer-aided analysis
  • VOCAL

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