Fibroblast heterogeneity in the cancer wound

Daniel Öhlund, Ela Elyada, David Tuveson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

657 Scopus citations

Abstract

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.

Original languageAmerican English
Pages (from-to)1503-1523
Number of pages21
JournalJournal of Experimental Medicine
Volume211
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

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