Firing Properties of Spinal Interneurons during Voluntary Movement. I. State-Dependent Regularity of Firing

Yifat Prut*, Steve I. Perlmutter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The firing properties of single spinal interneurons (INs) were studied in five awake, behaving monkeys performing isometric or auxotonic flexion-extension torques at the wrist. INs tended to fire tonically at rest (mean rate, 14 spikes (sp)/sec) and during generation of static torque (mean rate, 19 sp/sec in flexion, 24 sp/sec in extension). INs exhibited regular firing, with autocorrelation functions showing clear periodic features and a mean coefficient of variation of interspike intervals (CV) of 0.55 during production of static torque. For the population, there was an inverse correlation between CV and mean rate. However, 46% of the INs had task-dependent changes in regularity that were not predicted by changes in firing rate, suggesting that their firing pattern is determined not only by the intrinsic properties of the neurons but also by the properties of its synaptic inputs. INs showed two main response types to passive wrist displacement: biphasic and coactivation. Cells with these sensory responses had different, stereotypical temporal activity profiles and firing regularity during active movement. However, INs having correlational linkages with forearm muscles, identified as features in spike-triggered averages of electromyographic activity, did not exhibit unique responses or firing properties, although they tended to fire more regularly than other INs. This suggests the lack of a precise mapping of inputs to outputs for the spinal premotor network.

Original languageAmerican English
Pages (from-to)9600-9610
Number of pages11
JournalJournal of Neuroscience
Volume23
Issue number29
DOIs
StatePublished - 22 Oct 2003

Keywords

  • Firing pattern
  • Interneurons
  • Motor control
  • Primates
  • Spinal cord
  • Synchronization

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