TY - JOUR
T1 - First trimester exposure to cefuroxime
T2 - a prospective cohort study
AU - Berkovitch, M
AU - Segal-Socher, I
AU - Greenberg, R
AU - Bulkowshtein, M
AU - Arnon, J
AU - Merlob, P
AU - Or-Noy, A
PY - 2000/8
Y1 - 2000/8
N2 - AIMS: There are no published studies on the safety of cefuroxime use during pregnancy. We therefore investigated prospectively the possible teratogenic effect of intrauterine exposure to cefuroxime.METHODS: One hundred and six women who received cefuroxime during the first trimester of pregnancy were recruited from three teratogen information centres in Israel. Exposed women were paired for age, smoking habits and alcohol consumption with references being exposed to nonteratogenic antibiotics administered for the same indications.RESULTS: Maternal history, birthweight, gestational age at delivery, rates of live births, spontaneous abortions and fetal distress were comparable among the two groups. Rates of major malformations in the cefuroxime group (3.2%) did not differ from references (2%) (P = 0. 61, relative risk = 1.56, 95% confidence interval 0.27-9.15). There was a significantly higher rate of induced abortions among the cefuroxime exposed women as compared to the references (P = 0.04, relative risk = 3.33, 95% confidence interval 0.94-11.77).CONCLUSIONS: Our data may suggest that exposure to cefuroxime during the first trimester is probably not associated with an increased risk for malformations or spontaneous abortions; however, in light of the small sample size and the broad confidence limits, larger studies are needed to confirm these findings.
AB - AIMS: There are no published studies on the safety of cefuroxime use during pregnancy. We therefore investigated prospectively the possible teratogenic effect of intrauterine exposure to cefuroxime.METHODS: One hundred and six women who received cefuroxime during the first trimester of pregnancy were recruited from three teratogen information centres in Israel. Exposed women were paired for age, smoking habits and alcohol consumption with references being exposed to nonteratogenic antibiotics administered for the same indications.RESULTS: Maternal history, birthweight, gestational age at delivery, rates of live births, spontaneous abortions and fetal distress were comparable among the two groups. Rates of major malformations in the cefuroxime group (3.2%) did not differ from references (2%) (P = 0. 61, relative risk = 1.56, 95% confidence interval 0.27-9.15). There was a significantly higher rate of induced abortions among the cefuroxime exposed women as compared to the references (P = 0.04, relative risk = 3.33, 95% confidence interval 0.94-11.77).CONCLUSIONS: Our data may suggest that exposure to cefuroxime during the first trimester is probably not associated with an increased risk for malformations or spontaneous abortions; however, in light of the small sample size and the broad confidence limits, larger studies are needed to confirm these findings.
KW - Abnormalities, Drug-Induced
KW - Abortion, Induced/psychology
KW - Adolescent
KW - Adult
KW - Cefuroxime/pharmacology
KW - Cephalosporins/pharmacology
KW - Confidence Intervals
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Pregnancy
KW - Pregnancy Outcome
KW - Pregnancy Trimester, First
KW - Prospective Studies
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=0033855043&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2125.2000.00240.x
DO - 10.1046/j.1365-2125.2000.00240.x
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C2 - 10930968
SN - 0306-5251
VL - 50
SP - 161
EP - 165
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 2
ER -