TY - JOUR
T1 - Fish oil supplementation increases concentration of adiponectin in healthy dogs
AU - Mazaki-Tovi, M.
AU - Abood, S. K.
AU - Schenck, P. A.
PY - 2014/5
Y1 - 2014/5
N2 - OBJECTIVE: To determine the effect of fish oil supplementation on circulating concentrations of adiponectin, leptin, insulin, glucose, triglyceride and cholesterol in healthy dogs. METHODS: Twenty healthy adult dogs were administered 220 mg/kg of a fish oil supplement once daily for 30 days. At baseline, on supplement and 10 to 20 weeks off supplement, dogs were examined, body condition scores determined (range: 4 to 6), body measurements recorded for % body fat calculation and fasted blood samples collected. RESULTS: Serum concentrations of the measured individual and total n-3 polyunsaturated fatty acids increased following supplementation (P<0·001). Mean serum adiponectin concentration on supplement was 3·4 μg/mL (95% confidence interval: 0·8 to 6·0; P=0·006) higher than baseline, and 5·3 μg/mL (2·0 to 8·7; P<0·001) higher than off supplement. Concentrations of adiponectin off supplement were not different from baseline. There were no significant differences in weight, body condition scores, % body fat and concentrations of other measured analytes between baseline and on supplement. CLINICAL SIGNIFICANCE: Fish oil supplementation significantly increased circulating concentration of adiponectin in healthy non-obese dogs. Further investigation is warranted to determine whether this effect may be extended to obese dogs and to evaluate the potential role of fish oil supplementation in the management of disorders associated with low circulating adiponectin concentrations.
AB - OBJECTIVE: To determine the effect of fish oil supplementation on circulating concentrations of adiponectin, leptin, insulin, glucose, triglyceride and cholesterol in healthy dogs. METHODS: Twenty healthy adult dogs were administered 220 mg/kg of a fish oil supplement once daily for 30 days. At baseline, on supplement and 10 to 20 weeks off supplement, dogs were examined, body condition scores determined (range: 4 to 6), body measurements recorded for % body fat calculation and fasted blood samples collected. RESULTS: Serum concentrations of the measured individual and total n-3 polyunsaturated fatty acids increased following supplementation (P<0·001). Mean serum adiponectin concentration on supplement was 3·4 μg/mL (95% confidence interval: 0·8 to 6·0; P=0·006) higher than baseline, and 5·3 μg/mL (2·0 to 8·7; P<0·001) higher than off supplement. Concentrations of adiponectin off supplement were not different from baseline. There were no significant differences in weight, body condition scores, % body fat and concentrations of other measured analytes between baseline and on supplement. CLINICAL SIGNIFICANCE: Fish oil supplementation significantly increased circulating concentration of adiponectin in healthy non-obese dogs. Further investigation is warranted to determine whether this effect may be extended to obese dogs and to evaluate the potential role of fish oil supplementation in the management of disorders associated with low circulating adiponectin concentrations.
UR - http://www.scopus.com/inward/record.url?scp=84898814147&partnerID=8YFLogxK
U2 - 10.1111/jsap.12194
DO - 10.1111/jsap.12194
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C2 - 24611954
AN - SCOPUS:84898814147
SN - 0022-4510
VL - 55
SP - 247
EP - 253
JO - Journal of Small Animal Practice
JF - Journal of Small Animal Practice
IS - 5
ER -