TY - JOUR
T1 - Flexible categorization in the mouse olfactory bulb
AU - Kudryavitskaya, Elena
AU - Marom, Eran
AU - Shani-Narkiss, Haran
AU - Pash, David
AU - Mizrahi, Adi
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/4/26
Y1 - 2021/4/26
N2 - The ability to group sensory stimuli into categories is crucial for efficient interaction with a rich and ever-changing environment. In olfaction, basic features of categorical representation of odors were observed as early as in the olfactory bulb (OB). Categorical representation was described in mitral cells (MCs) as sudden transitions in responses to odors that were morphed along a continuum. However, it remains unclear to what extent such response dynamics actually reflect perceptual categories and decisions therein. Here, we tested the role of learning on category formation in the mouse OB, using in vivo two-photon calcium imaging and behavior. We imaged MC responses in naive mice and in awake behaving mice as they learned two tasks with different classification logic. In one task, a one-decision-boundary task, animals learned to classify odor mixtures based on the dominant compound in the mixtures. As expected, categorical representation of odors, which was evident already in naive animals, further increased following learning. In a second task, a multi-decision-boundary task, animals learned to classify odors independent of their chemical similarity. Here, odor discrimination was based on the meaning ascribed to them (either rewarding or not). Following the multi-decision-boundary task, odor representations by MCs reorganized according to the odor value in the new category. This functional reorganization was also reflected as a shift from predominantly excitatory odor responses to predominantly inhibitory odor responses. Our data show that odor representations by MCs are flexible, are shaped by task demands, and carry category-related information.
AB - The ability to group sensory stimuli into categories is crucial for efficient interaction with a rich and ever-changing environment. In olfaction, basic features of categorical representation of odors were observed as early as in the olfactory bulb (OB). Categorical representation was described in mitral cells (MCs) as sudden transitions in responses to odors that were morphed along a continuum. However, it remains unclear to what extent such response dynamics actually reflect perceptual categories and decisions therein. Here, we tested the role of learning on category formation in the mouse OB, using in vivo two-photon calcium imaging and behavior. We imaged MC responses in naive mice and in awake behaving mice as they learned two tasks with different classification logic. In one task, a one-decision-boundary task, animals learned to classify odor mixtures based on the dominant compound in the mixtures. As expected, categorical representation of odors, which was evident already in naive animals, further increased following learning. In a second task, a multi-decision-boundary task, animals learned to classify odors independent of their chemical similarity. Here, odor discrimination was based on the meaning ascribed to them (either rewarding or not). Following the multi-decision-boundary task, odor representations by MCs reorganized according to the odor value in the new category. This functional reorganization was also reflected as a shift from predominantly excitatory odor responses to predominantly inhibitory odor responses. Our data show that odor representations by MCs are flexible, are shaped by task demands, and carry category-related information.
KW - calcium imaging
KW - categorization
KW - generalization
KW - olfaction
KW - plasticity
KW - two photon
UR - http://www.scopus.com/inward/record.url?scp=85101691584&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2021.01.063
DO - 10.1016/j.cub.2021.01.063
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C2 - 33571434
AN - SCOPUS:85101691584
SN - 0960-9822
VL - 31
SP - 1616-1631.e4
JO - Current Biology
JF - Current Biology
IS - 8
ER -