TY - JOUR
T1 - Fluctuating hyper-hypocortisolaemia
T2 - A variant of Cushing's syndrome
AU - Leibowitz, Gil
AU - White, Anne
AU - Hadani, Moshe
AU - Gross, David J.
PY - 1997
Y1 - 1997
N2 - We present a patient with severe Cushing's syndrome secondary to an invasive pituitary tumour. Cortisol secretion fluctuated between severe hypercortisolaemia associated with features of Cushing's syndrome to recurrent symptomatic hypocortisolaemia. Normal ACTH precursors to ACTH ratio during the various stages of cortisol secretion indicated that periodic decreased prohormone processing did not contribute to the unique presentation in the patient. Thus, the the extreme fluctuations of plasma cortisol levels are most probably due to unexplained erratic changes of ACTH secretion.
AB - We present a patient with severe Cushing's syndrome secondary to an invasive pituitary tumour. Cortisol secretion fluctuated between severe hypercortisolaemia associated with features of Cushing's syndrome to recurrent symptomatic hypocortisolaemia. Normal ACTH precursors to ACTH ratio during the various stages of cortisol secretion indicated that periodic decreased prohormone processing did not contribute to the unique presentation in the patient. Thus, the the extreme fluctuations of plasma cortisol levels are most probably due to unexplained erratic changes of ACTH secretion.
UR - http://www.scopus.com/inward/record.url?scp=0030837365&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2265.1997.1210935.x
DO - 10.1046/j.1365-2265.1997.1210935.x
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C2 - 9274708
AN - SCOPUS:0030837365
SN - 0300-0664
VL - 46
SP - 759
EP - 763
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 6
ER -