Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Avia Tzubery; Naomi Melamed-Book; Edit Y. Tshuva

doi:10.1039/c7dt04828a

Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Avia Tzubery, Naomi Melamed-Book, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

Original language	English
Pages (from-to)	3669-3673
Number of pages	5
Journal	Dalton Transactions
Volume	47
Issue number	11
DOIs	https://doi.org/10.1039/c7dt04828a
State	Published - 2018

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

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10.1039/c7dt04828a

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abstract = "Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.",

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Fluorescent antitumor titanium(IV) salen complexes for cell imaging

Abstract

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