Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo

Dianne Daniels; Shirley Sharabi; David Last; David Guez; Sharona Salomon; Zion Zivli; David Castel; Alex Volovick; Javier Grinfeld; Itay Rachmilevich; Talia Amar; Sigal Liraz-Zaltsman; Narek Sargsyan; Yael Mardor; Sagi Harnof

doi:10.1016/j.ultrasmedbio.2018.01.010

Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo

Dianne Daniels^*, Shirley Sharabi, David Last, David Guez, Sharona Salomon, Zion Zivli, David Castel, Alex Volovick, Javier Grinfeld, Itay Rachmilevich, Talia Amar, Sigal Liraz-Zaltsman, Narek Sargsyan, Yael Mardor, Sagi Harnof

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm² (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm² (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.

Original language	American English
Pages (from-to)	1022-1030
Number of pages	9
Journal	Ultrasound in Medicine and Biology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2018.01.010
State	Published - May 2018

Bibliographical note

Funding Information:
This research is partly supported by grants from the MAGNET program of the Israeli Office of the Chief Scientist (OCS). We thank Amir Geva and Omer Naor.

Publisher Copyright:
© 2018 World Federation for Ultrasound in Medicine and Biology

Keywords

Auditory evoked potentials
Focused ultrasound
Neuromodulation

Access to Document

10.1016/j.ultrasmedbio.2018.01.010

Cite this

Daniels, D., Sharabi, S., Last, D., Guez, D., Salomon, S., Zivli, Z., Castel, D., Volovick, A., Grinfeld, J., Rachmilevich, I., Amar, T., Liraz-Zaltsman, S., Sargsyan, N., Mardor, Y., & Harnof, S. (2018). Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo. Ultrasound in Medicine and Biology, 44(5), 1022-1030. https://doi.org/10.1016/j.ultrasmedbio.2018.01.010

@article{aa5d8fe50c374dcdad70c24478aad04a,

title = "Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo",

abstract = "The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.",

keywords = "Auditory evoked potentials, Focused ultrasound, Neuromodulation",

author = "Dianne Daniels and Shirley Sharabi and David Last and David Guez and Sharona Salomon and Zion Zivli and David Castel and Alex Volovick and Javier Grinfeld and Itay Rachmilevich and Talia Amar and Sigal Liraz-Zaltsman and Narek Sargsyan and Yael Mardor and Sagi Harnof",

note = "Funding Information: This research is partly supported by grants from the MAGNET program of the Israeli Office of the Chief Scientist (OCS). We thank Amir Geva and Omer Naor. Publisher Copyright: {\textcopyright} 2018 World Federation for Ultrasound in Medicine and Biology",

year = "2018",

month = may,

doi = "10.1016/j.ultrasmedbio.2018.01.010",

language = "American English",

volume = "44",

pages = "1022--1030",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier USA",

number = "5",

}

Daniels, D, Sharabi, S, Last, D, Guez, D, Salomon, S, Zivli, Z, Castel, D, Volovick, A, Grinfeld, J, Rachmilevich, I, Amar, T, Liraz-Zaltsman, S, Sargsyan, N, Mardor, Y & Harnof, S 2018, 'Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo', Ultrasound in Medicine and Biology, vol. 44, no. 5, pp. 1022-1030. https://doi.org/10.1016/j.ultrasmedbio.2018.01.010

TY - JOUR

T1 - Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo

AU - Daniels, Dianne

AU - Sharabi, Shirley

AU - Last, David

AU - Guez, David

AU - Salomon, Sharona

AU - Zivli, Zion

AU - Castel, David

AU - Volovick, Alex

AU - Grinfeld, Javier

AU - Rachmilevich, Itay

AU - Amar, Talia

AU - Liraz-Zaltsman, Sigal

AU - Sargsyan, Narek

AU - Mardor, Yael

AU - Harnof, Sagi

N1 - Funding Information: This research is partly supported by grants from the MAGNET program of the Israeli Office of the Chief Scientist (OCS). We thank Amir Geva and Omer Naor. Publisher Copyright: © 2018 World Federation for Ultrasound in Medicine and Biology

PY - 2018/5

Y1 - 2018/5

N2 - The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.

AB - The goal of this study was to determine the feasibility of focused ultrasound–based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound–induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p < 0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications.

KW - Auditory evoked potentials

KW - Focused ultrasound

KW - Neuromodulation

UR - http://www.scopus.com/inward/record.url?scp=85042629372&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2018.01.010

DO - 10.1016/j.ultrasmedbio.2018.01.010

M3 - Article

C2 - 29501283

AN - SCOPUS:85042629372

SN - 0301-5629

VL - 44

SP - 1022

EP - 1030

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 5

ER -

Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this