Foot and mouth disease viruses are recurrently introduced to Israel and spread by extensively reared sheep and cattle: Insights from a whole-genome sequence analysis

Greta Ivanov, Eyal Klement*, Boris Gelman, Ehud Elnekave, Sharon Karniely*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Despite routine vaccination, Israel experiences recurrent outbreaks of foot and mouth disease (FMD). We analyzed VP1 coding sequences of viruses isolated during FMD outbreaks from 2001 to 2011 in Israel and neighboring nations. The Israeli strains were aligned with strains from neighboring countries in corresponding years, implying repeated FMD virus incursions. In 2007 a large FMD epidemic, caused by a serotype O virus, occurred in Israel. Bayesian analysis of whole-genome sequences of viruses isolated during this epidemic revealed predominant transmission among extensively farmed beef-cattle and small ruminants. Small ruminants were key in spreading to beef-cattle, which then transmitted the virus to feedlot-cattle. Wild gazelles had a minor role in transmission. The results may suggest probable transmission of FMD virus from the Palestinian Authority to Israel. Targeting extensive farms via enhanced surveillance and vaccination could improve FMDV control. Given cross-border transmission, a collaborative FMD mitigation strategy across the Middle-East is crucial.

Original languageAmerican English
Article number109950
JournalVirology
Volume590
DOIs
StatePublished - Feb 2024

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

  • Bayesian phylogenetic analysis
  • FMDV
  • Middle east region
  • Small ruminants
  • Transmission dynamics

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