TY - JOUR
T1 - Formation of celecoxib nanoparticles from volatile microemulsions
AU - Margulis-Goshen, Katrin
AU - Kesselman, Ellina
AU - Danino, Dganit
AU - Magdassi, Shlomo
PY - 2010/6
Y1 - 2010/6
N2 - A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.
AB - A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.
KW - Celecoxib
KW - Evaporation
KW - Microemulsion
KW - Organic nanoparticles
KW - Poorly soluble drug
UR - http://www.scopus.com/inward/record.url?scp=77953357896&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2010.04.012
DO - 10.1016/j.ijpharm.2010.04.012
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AN - SCOPUS:77953357896
SN - 0378-5173
VL - 393
SP - 231
EP - 238
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -