Formation of celecoxib nanoparticles from volatile microemulsions

Katrin Margulis-Goshen, Ellina Kesselman, Dganit Danino, Shlomo Magdassi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.

Original languageAmerican English
Pages (from-to)231-238
Number of pages8
JournalInternational Journal of Pharmaceutics
Issue number1-2
StatePublished - Jun 2010


  • Celecoxib
  • Evaporation
  • Microemulsion
  • Organic nanoparticles
  • Poorly soluble drug


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