@inproceedings{b113d5a2dad64394aa528e2581290107,
title = "Formation of drug nanoparticles from microemulsions",
abstract = "Reduction in particle size of poorly water-soluble drugs leads to enhanced dissolution and improved bioavailability. A new method for preparation of hydrophobic drug nanoparticles, in a form of water dispersible powder will be described. The method is based on rapid conversion of nanodroplets into nanoparticles, by evaporation of all volatile solvents from microemulsions containing a dissolved drug in the dispersed oil phase. The new method does not require any special instrumentation such as high pressure homogenizers since the nanodroplets are formed by spontaneous assembly. Typically, powders composed of either amorphous or crystalline particles at the size range of 10-100 nm are obtained. Dispersing these powders in water yields transparent systems. The simplicity and the low cost of the new processes make it very attractive for application for the pharmaceutical industry. Formation of nanometric powders by this process will be demonstrated for several hydrophobic drugs.",
keywords = "Celecoxib, Microemulsions, Nanoparticles, Simvastatin, Solubility enhancement",
author = "S. Magdassi and K. Margulis-Goshen",
year = "2010",
language = "אנגלית",
isbn = "9781439834152",
series = "Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010",
pages = "308--311",
booktitle = "Nanotechnology 2010",
note = "Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 ; Conference date: 21-06-2010 Through 24-06-2010",
}