Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Arkady Khoutorsky; Arnon Heyman; Oded Shoseyov; Micha E. Spira

doi:10.1021/nl201368w

Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Arkady Khoutorsky, Arnon Heyman, Oded Shoseyov, Micha E. Spira^*

^*Corresponding author for this work

Institute of Plant Sciences and Genetics in Agriculture

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

Original language	American English
Pages (from-to)	2901-2904
Number of pages	4
Journal	Nano Letters
Volume	11
Issue number	7
DOIs	https://doi.org/10.1021/nl201368w
State	Published - 13 Jul 2011

Keywords

SP1
lipid membrane
nanochannel
neuroelectronic interface
neurons

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10.1021/nl201368w

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abstract = "The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.",

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AU - Shoseyov, Oded

AU - Spira, Micha E.

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AB - The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

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KW - nanochannel

KW - neuroelectronic interface

KW - neurons

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Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

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Keywords

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