Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1

Arkady Khoutorsky, Arnon Heyman, Oded Shoseyov, Micha E. Spira*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

Original languageAmerican English
Pages (from-to)2901-2904
Number of pages4
JournalNano Letters
Volume11
Issue number7
DOIs
StatePublished - 13 Jul 2011

Keywords

  • SP1
  • lipid membrane
  • nanochannel
  • neuroelectronic interface
  • neurons

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