Formation of hydrophilic nanofibers from nanoemulsions through electrospinning

V. Gordon, G. Marom*, S. Magdassi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

This study presents a method for one step incorporation of lipophilic compounds in hydrophilic nanofibers. By this method nanodroplets of oil and of volatile solvent are entrapped within polymer nanofibers during an electrospinning process. While performing the process with a volatile oil with dissolved lipophilic material, such as the drug celecoxib, nanofiber-nanoparticle composites are formed. The polymer used to form the fibers is a high molecular weight poly(vinyl alcohol) which enables rapid dissolution and release of the incorporated lipophilic material. The resulting celecoxib nanoparticles that are embedded within the nanofiber are amorphous and their average size is in between 21 and 93 nm, thus potentially lead to their increased dissolution rate. The preparation of such a solid matrix containing nanodroplets or nanoparticles may be applied as a fast dissolving delivery system for water insoluble materials.

Original languageAmerican English
Pages (from-to)172-179
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume478
Issue number1
DOIs
StatePublished - 15 Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.

Keywords

  • Electrospinning
  • Emulsion
  • Fast dissolving delivery system
  • Lipophilic nanoparticles
  • Nanofibers

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