Formation of novel colloidal immunoclusters by surface active antibodies

S. Magdassi*, O. Toledano, Z. Zakay-Rhones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Surface active antibodies were formed by covalent attachment of hydrophobic groups to IgG molecules. The modification was carried out at various degrees of attachment and various chain lengths. These modified antibodies spontaneously formed new colloidal micelle-like particles, immunoclusters, which were viewed with a transmission electron microscope and evaluated by light scattering. We found that the size of the immunoclusters increased while either degree of attachment or chain-length were increased, and that the biological activity decreased with the increase of degree of modification.

Original languageAmerican English
Pages (from-to)435-439
Number of pages5
JournalJournal of Colloid and Interface Science
Volume175
Issue number2
DOIs
StatePublished - Nov 1995

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