Formation of Novel Octuplex DNA Molecules from Guanine Quadruplexes

Liat Katrivas; Natalie Fardian-Melamed; Dvir Rotem; Danny Porath; Alexander Kotlyar

doi:10.1002/adma.202006932

Formation of Novel Octuplex DNA Molecules from Guanine Quadruplexes

Liat Katrivas, Natalie Fardian-Melamed, Dvir Rotem, Danny Porath^*, Alexander Kotlyar^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Guanine quadruplex (G4)-DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4-DNA endows it with mechanical stability, robustness, and improved charge transport properties—attractive attributes for a molecular nanowire. The self-driven formation of a novel G4-DNA-based nanostructure, coined guanine octuplex (G8)-DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled-coil structure, which is found to be stable under different temperatures and surrounding conditions. G8-DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4-DNA. These, along with its high guanine content, make G8-DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.

Original language	American English
Article number	2006932
Journal	Advanced Materials
Volume	33
Issue number	8
DOIs	https://doi.org/10.1002/adma.202006932
State	Published - 24 Feb 2021

Bibliographical note

Funding Information:
L.K. and N.F.‐M. contributed equally to this work. This research was supported by the Israel Science Foundation (ISF grant 1589/14), the ISF−NSFC (grant 2556/17), the Ministry of Science & Technology, Israel (grant 3–16840), and by the Minerva Centre for bio‐hybrid complex systems. D.P. thanks the Etta and Paul Schankerman Chair of Molecular Biomedicine.

Funding Information:
L.K. and N.F.-M. contributed equally to this work. This research was supported by the Israel Science Foundation (ISF grant 1589/14), the ISF?NSFC (grant 2556/17), the Ministry of Science & Technology, Israel (grant 3?16840), and by the Minerva Centre for bio-hybrid complex systems. D.P. thanks the Etta and Paul Schankerman Chair of Molecular Biomedicine.

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

DNA nanoelectronics
guanine octuplex (G8-DNA)
guanine quadruplex (G4-DNA)

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10.1002/adma.202006932

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abstract = "Guanine quadruplex (G4)-DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4-DNA endows it with mechanical stability, robustness, and improved charge transport properties—attractive attributes for a molecular nanowire. The self-driven formation of a novel G4-DNA-based nanostructure, coined guanine octuplex (G8)-DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled-coil structure, which is found to be stable under different temperatures and surrounding conditions. G8-DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4-DNA. These, along with its high guanine content, make G8-DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.",

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author = "Liat Katrivas and Natalie Fardian-Melamed and Dvir Rotem and Danny Porath and Alexander Kotlyar",

note = "Funding Information: L.K. and N.F.‐M. contributed equally to this work. This research was supported by the Israel Science Foundation (ISF grant 1589/14), the ISF−NSFC (grant 2556/17), the Ministry of Science & Technology, Israel (grant 3–16840), and by the Minerva Centre for bio‐hybrid complex systems. D.P. thanks the Etta and Paul Schankerman Chair of Molecular Biomedicine. Funding Information: L.K. and N.F.-M. contributed equally to this work. This research was supported by the Israel Science Foundation (ISF grant 1589/14), the ISF?NSFC (grant 2556/17), the Ministry of Science & Technology, Israel (grant 3?16840), and by the Minerva Centre for bio-hybrid complex systems. D.P. thanks the Etta and Paul Schankerman Chair of Molecular Biomedicine. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",

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Formation of Novel Octuplex DNA Molecules from Guanine Quadruplexes

Abstract

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