Formation of organic nanoparticles from volatile microemulsions

Katrin Margulis-Goshen, Hadas Donio Netivi, Dan T. Major, Michael Gradzielski, Uri Raviv, Shlomo Magdassi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A method for preparation of nanoparticles of poorly water-soluble organic materials is presented. By this method, an oil-in-water microemulsion containing a volatile solvent with dissolved model material, propylparaben, undergoes solvent evaporation and conversion into nanoparticles by spray drying. The resulting powder can be easily dispersed in water to give a clear, stable dispersion of nanoparticles with a high loading of propylparaben. By filtration of this dispersion it was found that more than 95 wt.% of the dispersed propylparaben is in particles of less than 450 nm. X-ray diffraction revealed that propylparaben is present as nanocrystals of 40-70 nm. After dispersion of the powder in water, formation of large crystals rapidly occurs. Addition of polyvinylpyrrolidone (PVP) prevented crystal growth during dispersion of the powder in water. The inhibition of propylparaben crystal growth by PVP was studied by molecular dynamic simulations that addressed the binding of PVP to the propylparaben crystal. A comparison was made between PVP and polyvinylalcohol, which did not display crystal inhibition properties.

Original languageAmerican English
Pages (from-to)283-292
Number of pages10
JournalJournal of Colloid and Interface Science
Volume342
Issue number2
DOIs
StatePublished - 15 Feb 2010

Keywords

  • Crystallization inhibitor
  • Crystallization prevention
  • Evaporation
  • Microemulsion
  • Organic nanoparticles
  • PVP
  • Poorly-soluble drug

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