Formation of vaccinia virus DNA-protein complex in the presence of isatin β thiosemicarbazone (IBT)

E. Katz, E. Margalith, B. Winer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The association of newly synthesized vaccinia virus DNA with proteins in infected HeLa cells was followed. A shift from a high density to a low density complex occurred between 3 and 6 h after infection. This process was not affected by isatin β thiosemicarbazone (IBT), an inhibitor of pox virus growth. At 22 h after infection in the absence of IBT, mature virions of high density were observed; however, in the presence of the drug, high density DNA-protein complexes, which lack the two main virus core polypeptides were formed.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalJournal of General Virology
Volume40
Issue number3
DOIs
StatePublished - 1978

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