TY - JOUR
T1 - Formation of vaccinia virus DNA-protein complex in the presence of isatin β thiosemicarbazone (IBT)
AU - Katz, E.
AU - Margalith, E.
AU - Winer, B.
PY - 1978
Y1 - 1978
N2 - The association of newly synthesized vaccinia virus DNA with proteins in infected HeLa cells was followed. A shift from a high density to a low density complex occurred between 3 and 6 h after infection. This process was not affected by isatin β thiosemicarbazone (IBT), an inhibitor of pox virus growth. At 22 h after infection in the absence of IBT, mature virions of high density were observed; however, in the presence of the drug, high density DNA-protein complexes, which lack the two main virus core polypeptides were formed.
AB - The association of newly synthesized vaccinia virus DNA with proteins in infected HeLa cells was followed. A shift from a high density to a low density complex occurred between 3 and 6 h after infection. This process was not affected by isatin β thiosemicarbazone (IBT), an inhibitor of pox virus growth. At 22 h after infection in the absence of IBT, mature virions of high density were observed; however, in the presence of the drug, high density DNA-protein complexes, which lack the two main virus core polypeptides were formed.
UR - http://www.scopus.com/inward/record.url?scp=0018080340&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-40-3-695
DO - 10.1099/0022-1317-40-3-695
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C2 - 690618
AN - SCOPUS:0018080340
SN - 0022-1317
VL - 40
SP - 695
EP - 699
JO - Journal of General Virology
JF - Journal of General Virology
IS - 3
ER -