TY - JOUR
T1 - Formulation for slow release of oral radiation-protection drugs
AU - Abdulrazik, M.
AU - Shani, J.
AU - Benita, S.
AU - Samuni, A.
AU - Donbrow, M.
AU - Yerushalmi, A.
PY - 1984
Y1 - 1984
N2 - Cysteine and cysteamine, two effective radioprotectants in mammals, were compressed into tablets with a matrix composed of ethylcellulose and stearic acid at various proportions. The concentration of the unoxidized drug was monitored continuously for 8-16 h, as a parameter for the residual drug in the tablets with time, in vitro. Also, in vivo studies with tablets implanted into stomachs of rats, at various time intervals before their whole-body irradiation, were carried out. A correlation was obtained in the in vitro studies between the stearic acid/ethylcellulose ratio and the release rate of both radioprotectants, and the Higuchi's diffusional mechanism was demonstrated. In vivo, the best survival ratios were obtained when 8 h lapsed between implantation of the tablets in the stomachs and the irradiation. It is concluded that there is a distinct correlation between the in vitro release of the drugs and their in vivo efficacy as radioprotectants.
AB - Cysteine and cysteamine, two effective radioprotectants in mammals, were compressed into tablets with a matrix composed of ethylcellulose and stearic acid at various proportions. The concentration of the unoxidized drug was monitored continuously for 8-16 h, as a parameter for the residual drug in the tablets with time, in vitro. Also, in vivo studies with tablets implanted into stomachs of rats, at various time intervals before their whole-body irradiation, were carried out. A correlation was obtained in the in vitro studies between the stearic acid/ethylcellulose ratio and the release rate of both radioprotectants, and the Higuchi's diffusional mechanism was demonstrated. In vivo, the best survival ratios were obtained when 8 h lapsed between implantation of the tablets in the stomachs and the irradiation. It is concluded that there is a distinct correlation between the in vitro release of the drugs and their in vivo efficacy as radioprotectants.
UR - http://www.scopus.com/inward/record.url?scp=0021237853&partnerID=8YFLogxK
U2 - 10.1016/0047-0740(84)90032-9
DO - 10.1016/0047-0740(84)90032-9
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C2 - 6610665
AN - SCOPUS:0021237853
SN - 0047-0740
VL - 11
SP - 53
EP - 54
JO - International Journal of Nuclear Medicine and Biology
JF - International Journal of Nuclear Medicine and Biology
IS - 1
ER -