Abstract
Small angle X-ray scattering (SAXS) is an increasingly common technique for low-resolution structural characterization of molecules in solution. SAXS experiment determines the scattering intensity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the interface and capabilities of the FoXS web server (http://salilab.org/foxs).
| Original language | English |
|---|---|
| Article number | gkq461 |
| Pages (from-to) | W540-W544 |
| Journal | Nucleic Acids Research |
| Volume | 38 |
| Issue number | SUPPL. 2 |
| DOIs | |
| State | Published - 27 May 2010 |
| Externally published | Yes |
Bibliographical note
Funding Information:Weizmann Institute Advancing Women in Science Postdoctoral Fellowship to DSD; Sandler Family Supporting Foundation, National Institutes of Health (R01 GM083960); National Institutes of Health (U54 RR022220); National Institutes of Health (PN2 EY016525); DOE program Integrated Diffraction Analysis Technologies (IDAT), Pfizer Inc. SIBYLS beamline at Lawrence Berkeley National Laboratory. Funding for open access charge: National Institutes of Health (R01 GM083960).