FoXS: a web server for rapid computation and fitting of SAXS profiles

Dina Schneidman-Duhovny, Michal Hammel, Andrej Sali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

418 Scopus citations

Abstract

Small angle X-ray scattering (SAXS) is an increasingly common technique for low-resolution structural characterization of molecules in solution. SAXS experiment determines the scattering intensity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the interface and capabilities of the FoXS web server (http://salilab.org/foxs).

Original languageAmerican English
Article numbergkq461
Pages (from-to)W540-W544
JournalNucleic Acids Research
Volume38
Issue numberSUPPL. 2
DOIs
StatePublished - 27 May 2010
Externally publishedYes

Bibliographical note

Funding Information:
Weizmann Institute Advancing Women in Science Postdoctoral Fellowship to DSD; Sandler Family Supporting Foundation, National Institutes of Health (R01 GM083960); National Institutes of Health (U54 RR022220); National Institutes of Health (PN2 EY016525); DOE program Integrated Diffraction Analysis Technologies (IDAT), Pfizer Inc. SIBYLS beamline at Lawrence Berkeley National Laboratory. Funding for open access charge: National Institutes of Health (R01 GM083960).

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