TY - JOUR
T1 - Frequent blood-brain barrier disruption in the human cerebral cortex
AU - Tomkins, Oren
AU - Kaufer, Daniela
AU - Korn, Akiva
AU - Shelef, Ilan
AU - Golan, Haim
AU - Reichenthal, Eli
AU - Soreq, Hermona
AU - Friedman, Alon
PY - 2001
Y1 - 2001
N2 - 1. The blood-brain barrier (BBB) protects the brain from circulating xenobiotic agents. The pathophysiology, time span, spatial pattern, and pathophysiological consequences of BBB disruptions are not known. 2. Here, we report the quantification of BBB disruption by measuring enhancement levels in computerized tomography brain images. 3. Pathological diffuse enhancement associated with elevated albumin levels in the cerebrospinal fluid (CSF) was observed in the cerebral cortex of 28 out of 43 patients, but not in controls. Four patients displayed weeks-long focal BBB impairment. In 19 other patients, BBB disruption was significantly associated with elevated blood pressure, body temperature, serum cortisol, and stress-associated CSF "readthrough" acetylcholinesterase. Multielectrode electroencephalography revealed enhanced slow-wave activities in areas of focal BBB disruption. Thus, quantification of BBB disruption using minimally invasive procedures, demonstrated correlations with molecular, clinical, and physiological stress-associated indices. 4. These sequelae accompany a wide range of neurological disorders, suggesting that persistent, detrimental BBB disruption is considerably more frequent than previously assumed.
AB - 1. The blood-brain barrier (BBB) protects the brain from circulating xenobiotic agents. The pathophysiology, time span, spatial pattern, and pathophysiological consequences of BBB disruptions are not known. 2. Here, we report the quantification of BBB disruption by measuring enhancement levels in computerized tomography brain images. 3. Pathological diffuse enhancement associated with elevated albumin levels in the cerebrospinal fluid (CSF) was observed in the cerebral cortex of 28 out of 43 patients, but not in controls. Four patients displayed weeks-long focal BBB impairment. In 19 other patients, BBB disruption was significantly associated with elevated blood pressure, body temperature, serum cortisol, and stress-associated CSF "readthrough" acetylcholinesterase. Multielectrode electroencephalography revealed enhanced slow-wave activities in areas of focal BBB disruption. Thus, quantification of BBB disruption using minimally invasive procedures, demonstrated correlations with molecular, clinical, and physiological stress-associated indices. 4. These sequelae accompany a wide range of neurological disorders, suggesting that persistent, detrimental BBB disruption is considerably more frequent than previously assumed.
KW - Acetylcholinesterase
KW - Blood-brain barrier
KW - Cerebral cortex
KW - Computerized tomography
UR - http://www.scopus.com/inward/record.url?scp=0035565747&partnerID=8YFLogxK
U2 - 10.1023/A:1015147920283
DO - 10.1023/A:1015147920283
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C2 - 12043841
AN - SCOPUS:0035565747
SN - 0272-4340
VL - 21
SP - 675
EP - 691
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 6
ER -