From bipotent neuromesodermal progenitors to neural-mesodermal interactions during embryonic development

Nitza Kahane, Chaya Kalcheim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


To ensure the formation of a properly patterned embryo, multiple processes must operate harmoniously at sequential phases of development. This is implemented by mutual interactions between cells and tissues that together regulate the segregation and specification of cells, their growth and morphogenesis. The formation of the spinal cord and paraxial mesoderm derivatives exquisitely illustrate these processes. Following early gastrulation, while the vertebrate body elongates, a population of bipotent neuromesodermal progenitors resident in the posterior region of the embryo generate both neural and mesodermal lineages. At later stages, the somitic mesoderm regulates aspects of neural patterning and differentiation of both central and peripheral neural progenitors. Reciprocally, neural precursors influence the paraxial mesoderm to regulate somite-derived myogenesis and additional processes by distinct mechanisms. Central to this crosstalk is the activity of the axial notochord, which, via sonic hedgehog signaling, plays pivotal roles in neural, skeletal muscle and cartilage ontogeny. Here, we discuss the cellular and molecular basis underlying this complex developmental plan, with a focus on the logic of sonic hedgehog activities in the coordination of the neural-mesodermal axis.

Original languageAmerican English
Article number9141
JournalInternational Journal of Molecular Sciences
Issue number17
StatePublished - 24 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cell differentiation
  • Dermomyotome
  • Floor plate
  • Lateral plate mesoderm
  • Motoneurons
  • Muscle
  • Neural tube
  • Notochord
  • Sclerotome
  • Somite


Dive into the research topics of 'From bipotent neuromesodermal progenitors to neural-mesodermal interactions during embryonic development'. Together they form a unique fingerprint.

Cite this