From Nose to Brain: Un-Sensed Electrical Currents Applied in the Nose Alter Activity in Deep Brain Structures

Tali Weiss*, Sagit Shushan, Aharon Ravia, Avital Hahamy, Lavi Secundo, Aharon Weissbrod, Aya Ben-Yakov, Yael Holtzman, Smadar Cohen-Atsmoni, Yehudah Roth, Noam Sobel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Rules linking patterns of olfactory receptor neuron activation in the nose to activity patterns in the brain and ensuing odor perception remain poorly understood. Artificially stimulating olfactory neurons with electrical currents and measuring ensuing perception may uncover these rules. We therefore inserted an electrode into the nose of 50 human volunteers and applied various currents for about an hour in each case. This induced assorted non-olfactory sensations but never once the perception of odor. To validate contact with the olfactory path, we used functional magnetic resonance imaging to measure resting-state brain activity in 18 subjects before and after un-sensed stimulation. We observed stimulation-induced neural decorrelation specifically in primary olfactory cortex, implying contact with the olfactory path. These results suggest that indiscriminate olfactory activation does not equate with odor perception. Moreover, this effort serendipitously uncovered a novel path for minimally invasive brain stimulation through the nose.

Original languageAmerican English
Pages (from-to)4180-4191
Number of pages12
JournalCerebral Cortex
Volume26
Issue number11
DOIs
StatePublished - 1 Oct 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author 2016.

Keywords

  • brain stimulation
  • default-mode network
  • olfactory cortex
  • olfactory epithelium
  • olfactory perception
  • resting-state activity

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