From peptides to proteins: lessons from my years at the Centre for Protein Engineering

Assaf Friedler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The MRC Centre for Protein Engineering (CPE) hosted and trained many scientists over the years. It is a unique research environment that shaped the career of many scientists in all aspects. These include research directions and methodologies, but even more important - issues such as how to approach scientific problems and how to manage a research team. Alan Fersht was the director of the CPE when I joined it as a postdoc in the year 2000. In the current article for the PEDS special CPE issue, I will review how my scientific research and my approach to science developed from the days I arrived to the CPE as a young peptide chemist and throughout the years I spent at the CPE, and how it shaped my current research interests and attitude. I will focus on two major fields: (i) Using peptides to study and modulate the structure and interactions of proteins; (ii) Using quantitative biophysical methods to study proteins and their interactions at the molecular level. The Author 2010. Published by Oxford University Press.

Original languageAmerican English
Pages (from-to)241-245
Number of pages5
JournalProtein Engineering, Design and Selection
Volume24
Issue number1-2
DOIs
StatePublished - Jan 2011

Bibliographical note

Funding Information:
A.F. was supported during his post-doc at the CPE by a long-term fellowship from the Human Frontier Science Program Organization. A.F. is currently supported by a starting grant from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement n° 203413.

Keywords

  • biophysics
  • peptides
  • protein engineering
  • protein-protein interactions
  • proteins

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