From phosphonates to catalytic antibodies. a novel route to phosphonoester transition state analogs and haptens

Bernard S. Green; Zelig Eshhar

doi:10.1080/10426509308032374

From phosphonates to catalytic antibodies. a novel route to phosphonoester transition state analogs and haptens

Bernard S. Green
, Zelig Eshhar

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We present here a newly developed approach based on DBU catalyzed transesterification of bis-PNP-phosphonates, used for the preparation of phosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme-like properties.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	76
Issue number	1-4
DOIs	https://doi.org/10.1080/10426509308032374
State	Published - 1 Mar 1993

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abstract = "We present here a newly developed approach based on DBU catalyzed transesterification of bis-PNP-phosphonates, used for the preparation of phosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme-like properties.",

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AU - Green, Bernard S.

AU - Eshhar, Zelig

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N2 - We present here a newly developed approach based on DBU catalyzed transesterification of bis-PNP-phosphonates, used for the preparation of phosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme-like properties.

AB - We present here a newly developed approach based on DBU catalyzed transesterification of bis-PNP-phosphonates, used for the preparation of phosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme-like properties.

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From phosphonates to catalytic antibodies. a novel route to phosphonoester transition state analogs and haptens

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