From pills to programs: Lessons from medicine for developing effective lifestyle interventions

Laura J. Rosen; Orly Manor; David L. Brody; Dan Engelhard; Rony A. Shtarkshall; David Zucker

doi:10.1016/j.ypmed.2009.03.010

From pills to programs: Lessons from medicine for developing effective lifestyle interventions

Laura J. Rosen^*, Orly Manor, David L. Brody, Dan Engelhard, Rony A. Shtarkshall, David Zucker

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To propose a scheme for comprehensive development and evaluation of lifestyle interventions. Methods: We adapted the four-phase system used in drug development, the engine of progress in medicine for decades, to construct a system for developing lifestyle intervention programs. Results: Phase I: The intervention is constructed and tested with a small number of individuals. Acceptability and feasibility are assessed. Evaluation is primarily qualitative. Phase II: Effectiveness on intermediate endpoints (e.g. behavior) is tested in a real field setting, with a limited number of individuals, using a before-and-after design. An iterative process of testing and refinement may be necessary. Phase III: The effectiveness of the intervention on health-related outcomes is tested, using, where possible, a randomized design. Phase IV: Large-scale implementation and penetration are assessed in other populations. Process variables and local and national health indicators are studied. The development and evaluation of our hygiene intervention, which took place in Jerusalem from 1999 to 2001, is presented as a case study. Conclusions: Adaptation of the phased system of drug development to lifestyle interventions is a conceptually simple approach to building effective, sustainable programs for community-based public health.

Original language	English
Pages (from-to)	12-18
Number of pages	7
Journal	Preventive Medicine
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.ypmed.2009.03.010
State	Published - Aug 2009

Bibliographical note

Funding Information:
The authors gratefully acknowledge grants received from: The Chief Scientist's Office of the Ministry of Health (evaluation); Associate Director General's Unit for Health Promotion of the Ministry of Health (intervention); and the National Institute for Health Services Research (evaluation). We are also indebted to the Preschool and Public Health Departments of the Municipality of Jerusalem for logistical assistance. The authors also thank Prof. Jochanan Benbassat for editorial assistance.

Keywords

Clinical trials
Lifestyle
Program development
Program evaluation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ypmed.2009.03.010

Cite this

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abstract = "Objective: To propose a scheme for comprehensive development and evaluation of lifestyle interventions. Methods: We adapted the four-phase system used in drug development, the engine of progress in medicine for decades, to construct a system for developing lifestyle intervention programs. Results: Phase I: The intervention is constructed and tested with a small number of individuals. Acceptability and feasibility are assessed. Evaluation is primarily qualitative. Phase II: Effectiveness on intermediate endpoints (e.g. behavior) is tested in a real field setting, with a limited number of individuals, using a before-and-after design. An iterative process of testing and refinement may be necessary. Phase III: The effectiveness of the intervention on health-related outcomes is tested, using, where possible, a randomized design. Phase IV: Large-scale implementation and penetration are assessed in other populations. Process variables and local and national health indicators are studied. The development and evaluation of our hygiene intervention, which took place in Jerusalem from 1999 to 2001, is presented as a case study. Conclusions: Adaptation of the phased system of drug development to lifestyle interventions is a conceptually simple approach to building effective, sustainable programs for community-based public health.",

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From pills to programs: Lessons from medicine for developing effective lifestyle interventions

Abstract

Bibliographical note

Keywords

UN SDGs

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