FTO: Linking m6a demethylation to adipogenesis

Moshe Shay Ben-Haim; Sharon Moshitch-Moshkovitz; Gideon Rechavi

doi:10.1038/cr.2014.162

FTO: Linking m⁶a demethylation to adipogenesis

Moshe Shay Ben-Haim
, Sharon Moshitch-Moshkovitz
, Gideon Rechavi^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

94 Scopus citations

Abstract

Polymorphism of the FTO gene encoding an N⁶-methyladenosine (m⁶A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

Original language	English
Pages (from-to)	3-4
Number of pages	2
Journal	Cell Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1038/cr.2014.162
State	Published - 5 Jan 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 IBCB, SIBS, CAS. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/cr.2014.162

Cite this

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