TY - JOUR
T1 - Function of phospholipids in rececptors
AU - Dikstein, S.
AU - Sulman, F. G.
PY - 1965/5
Y1 - 1965/5
N2 - The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 % acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.
AB - The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 % acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.
UR - http://www.scopus.com/inward/record.url?scp=0013782544&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(65)90091-2
DO - 10.1016/0006-2952(65)90091-2
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C2 - 5891538
AN - SCOPUS:0013782544
SN - 0006-2952
VL - 14
SP - 739
EP - 742
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 5
ER -