Function of phospholipids in rececptors

S. Dikstein; F. G. Sulman

doi:10.1016/0006-2952(65)90091-2

Function of phospholipids in rececptors

S. Dikstein^*
, F. G. Sulman

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 % acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.

Original language	English
Pages (from-to)	739-742
Number of pages	4
Journal	Biochemical Pharmacology
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0006-2952(65)90091-2
State	Published - May 1965

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title = "Function of phospholipids in rececptors",

abstract = "The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 \% acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.",

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AU - Sulman, F. G.

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N2 - The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 % acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.

AB - The rectus abdominis muscle of Bufo viridis loses its responsiveness to acetylcholine when extracted for 2 min with 25 % acetone. Washing with frog Ringer solution slowly restores contractions. Addition of phosphatidylethanolamine or phosphatidylserine enormously speeds up the recovery of sensitivity towards acetylcholine. Lecithin is less active, while heparin, alpha-glycerophosphate and tween-20 are inactive. Qualitatively, the same holds true for the noradrenaline-induced contraction of rabbit-uterus. This finding is quite similar to the acetone-induced inactivation and the phospholipid-borne reactivation of electron transport particles within the mitochondria. We, therefore, assume that neurohormones and other pharmacological agents exert their activity by modifying a transducer system present in the cell membrane.

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Function of phospholipids in rececptors

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